ISHLT Pulmonary Function Test/Spirometry and Co-Relationships with Lung Transplantation and BOS Research Grant

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Bronchiolitis Obliterans Syndrome (BOS) is a severe and progressive lung disease that occurs in individuals who have undergone lung transplantation. BOS is characterized by inflammation and scarring of the small airways in the lungs, leading to a decline in pulmonary function and respiratory symptoms.

Pulmonary function testing is a crucial tool for diagnosing and monitoring BOS. Specifically, spirometry and forced expiratory volume in one second (FEV1) are the most used tests to assess lung function in patients with BOS. These tests allow for the early detection of changes in lung function, which can prompt early intervention and potentially improve outcomes.

Despite the importance of pulmonary function testing in BOS, there are still significant gaps in our understanding of the disease and its relationship with lung function testing. Therefore, further research is needed to identify novel biomarkers and better understand the pathophysiology of BOS, ultimately leading to improved diagnosis, treatment, and outcomes for patients.

Purpose

The purpose of this grant is to fund research that aims to improve the understanding of the relationship between pulmonary function testing, lung transplantation, and the development and progression of BOS (If PFT measure can become predictor for the BOS development). Specifically, this grant will support research projects that focus on identifying novel ways for early detection and monitoring of BOS using pulmonary function testing, investigating the pathophysiology of BOS and its impact on lung function, and identifying trajectories of lung function decline in patients with BOS over time.

This research will aim to fill significant gaps in our understanding of BOS and pulmonary function testing, and its relationship, ultimately leading to improved diagnosis, treatment, and possibly survival outcomes for patients with BOS.

Grant Details

One grant of up to $20,000 will be awarded for one year.

Current Recipient