2019

Maria-Nieves Sanz, PhD
Berne University Hospital, Berne, Switzerland
"Role of Mitochondrial Damage-Associated Molecular Patterns (mtDAMPs) in Heart Transplantation with Donation after Circulatory Death"
 

2018

Ei Miyamoto, MD
Latner Thoracic Surgery Research Laboratories, Toronto, ON, Canada
"Pre-Transplant Lung Allograft Cell Therapy with Expanded Recipient Regulatory T Cells: An Ex-Vivo Lung Perfusion Study"
 

2017

Ramiro Fernandez, MD
Feinberg School of Medicine, Chicago, IL, USA
"Lung-Restricted Antibodies Lead to Lung Allograft Rejection"
 

ISHLT/Enduring Hearts Research Fellowship Award

Jane O, MD
Massachusetts General Hospital, Boston, MA, USA
"En Bloc Donor Thymus Cotransplantation to Achieve Tolerance in Pediatric Heart Recipients"

This project was fully funded by a gift from Enduring Hearts

 

2016

Hsi-Min Hsiao, PhD
Washington University in St. Louis, St. Louis, MO, USA
"The role of CD11c+ cells in maintaining tolerance after lung transplantation"

Nikolaos Skartsis, MD, PhD
University of California, San Francisco, CA, USA
"The protective role of SPI6 in adoptively transferred regulatory T cells in transplantation"

Corey Tabit, MD, MBA, MPH
The University of Chicago, Chicago, IL, USA
"Molecular Mechanisms of Angiodysplasia in Human Patients with Continuous-Flow Left Ventricular Assist Devices"
 

2015

Jonathan Merola, MD
Yale University, New Haven, CT, USA
"Elucidating Mechanisms of Alloantibody-Mediated Cardiac Allograft Vasculopathy: The Role of Class I and II MHC in Vascular Endothelial Cells"
 

2014

Charles Evans, MD
University of Maryland School of Medicine, Baltimore, MD, USA
"The effect of mesenchymal stem cells in delayed donor criteria lung transplantation"

Christine Lin, MD
University of Colorado, Aurora, CO, USA
"The Role of NK cells in antibody-mediated rejection and chronic allograft dysfunction"

Stijn Verleden, PhD
KU Leuven, Leuven, Belgium
"Unraveling the pathophysiology of restrictive allograft syndrome after lung transplantation"
 

2013

Nikolaos Diakos, MD
University of Utah, Salt Lake City, UT, USA
"Humans as a model organism to study medabolic changes in heart failure and myocardial recovery"

Raymond Givens, MD, PhD
Columbia University, New York, NY, USA
"MicroRNA Profiling in Patients with Orthotopic Heart Transplant Rejection"

Pablo Sanchez, MD, PhD
University of Maryland, Baltimore, MD, USA
"Increasing the number and outcomes of lung transplants by using mesenchymal stem cells"
 

2012

Stephen C. Juvet, MD, FRCPC
University Health Network, Toronto, Ontario, Canada
"Enhancing Regulatory T Cell Stability in the Presence of Allograft Inflammation and Ischemia-reperfusion Injury"

Maria Lucia L. Madariga, MD
Massachusetts General Hospital, Boston, MA, USA
"Amelioration of the Deletrious Effects of Donor Brain Death by Cytokine Blockade and Ex Vivo Allograft Perfusion in Fully Mismatched Miniature Swine"

Jessica H. Spahn, PhD
Washington University, St. Louis, MO, USA
"Neutrophil Trafficking to the Lung During Pulmonary Ischemia-reperfusion Injury"

Konstantinos Malliaras, PhD
Cedars-Sinai Medical Center, Los Angeles, CA, USA
"Percutaneous Catheter-guided Endomyocardial Delivery of Allogeneic Cardiospheres for Heart Regeneration in a Porcine Model of Chronic Ischemic Cardiomyopathy and Heart Failure"
 

2011

Alejandro Bribriesco, MD
Washington University in St. Louis, MO, USA
"The Role of CD8+ Regulatory T. Cells in Lung Allograft Acceptance"

Alexey Dashkevich, MD
University Frieburg, Germany
"Molecular and Gene Therapy for Heart Transplantation: Targeting of Lymph Angiogenesis as a New Immunomodulatory Approach"

Patricia E. de Almeida, DVM, MS, PhD
Stanford University, Stanford, CA, USA
"Patient Specific Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Modeling Familial Dilated Cardiomyopathy"

Tiago Machuca, MD, PhD
University of Toronto, Ontario, Canada
"Combining Anti-inflammatory and Pro-Tolerogenic Ex Vivo Treatment Using Interleukin-10 in a Pre-Clinical Model of Lung Transplantation"
 

2010

Esme Dijke, PhD
University of Alberta, Canada
"To B or Not to B? - The Fate of B-cell Memory in B-cell Tolerance After ABO-incompatible Heart Transplantation in Infants"

Smita Sihag, MD
Massachusetts General Hospital, Boston, MA, USA
"Gene Expression Signatures and Mechanistic Pathways of Tolerance and Rejection in Orthotopic Swine Lung Allografts"

Sumiharu Yamamoto, MD
Washington University in St. Louis, MO, USA
"The Role of Emergency Granulopoiesis in Linking Primary Graft Dysfunction to the Inhibition of Mouse Lung Allograft Acceptance"

Khurram Shahzad, MD
Columbia University Medical Center, New York, NY, USA
"Immune Mechanisms of Graft Dysfunction after Heart Transplantation - Identification of Potential Biomarkers"

Nina Pilat, MSc, PhD
Medical University of Vienna, Austria
"The Role and Therapeutic Use of Regulatory T-cells in Chimerism-based Heart Graft Tolerance"
 

2009

Hua Shen, MD, PhD
Yale University, New Haven, CT, USA
"Impact of CD14 and CD36 Signaling in Co-Stimulatory Blockade Extension of Allograft Survival"

Tobias Deuse, MD, PhD
University of Hamburg, Germany
"Allogeneic Stem Cell Transplantation for Ischemic Myocardium: Immunobiology of Stem Cells"

Masahiro Miyajima, MD, PhD
Harvard University, Boston, MA, USA
"Role of T Regulatory Cells and Natural Killer Cells in the In Vivo Promotion of Coronary Allograft Vasculopathy"

Shin Hirayama, MD, PhD
University of Toronto, Canada
"Role of Genetically Engineered IL-10 Producing T Regulatory Trl-like Cells in Immunoregulation After Lung Transplantation"
 

2008

Jonathan Choy, PhD
Yale University, New Haven, CT, USA
"Regulation of iNOS in Human T Cells: Role of SDF-1"

Satoshi Itoh, MD
Stanford School of Medicine, Stanford, CA, USA
"Nanoscale Therapeutics: A Novel Approach to Cardiac Protection - PMM2.1.2 Nanoparticles Attenuate Cardiac Allograft Vasculopathy"

Tereza Martinu, MD
Duke University, Durham, NC, USA
"Role of CXC Chemokines at the Innate-Adaptive Interface of Alloimmune Lung Injury"

Deepti Saini, PhD
Washington University School of Medicine, St. Louis, MO, USA
"Immune Mechanisms of Rejection in Human Lung Allografts"

Atsushi Shiozaki, MD, PhD
University of Toronto, Canada, USA
"Roles of XB130, a Novel Regulator of PI3K/Akt Pathway, in Airway Epithelial Injury and Repair Post Lung Transplantation"

Seiichiro Sugimoto, MD, PhD
Washington University School of Medicine, St. Louis, MO, USA
"The Role of IL-6 in Ischemia Reperfusion Injury-Induced Abrogation of Mouse Lung Transplant Acceptance"
 

2007

Satish N. Nadig, MD
Beth-Israel Deaconess Med Ctr, Harvard Medical School, Boston, MA, USA
"The Impact of Regulatory T cells on Transplant Arteriosclerosis in the Humanized Mouse Model"

Timothy M. Millington, MD
Massachusetts General Hospital, Boston, MA, USA
"Expanding Primate Tregs Ex-Vivo to Facilitate Tolerance in Vivo"

Howard J. Huang, MD
Washington University, St. Louis, MO, USA
"The Role of MyD88-Dependent Inflammatory Signaling in a Novel Mouse Model of Orthotopic Lung Transplantation"

Mylvaganam Jeyakanthan
University of Alberta, Edmonton, AB, Canada
"Nanosystems in Transplantation: Neonatal Tolerance Induction by Blood Group Antigen-Expressing Implants"

J. Raymond Fitzpatrick, III, MD
Hospital of the University of Pennsylvania, Philadelphia, PA, USA
"Cyclin A2 Mediated Cardiomyocyte Regeneration Therapy for Heart Failure"

Sonja Schrepfer, MD
Stanford University School of Medicine, Stanford, CA, USA
"Stem Cell Transplantation for the Ischemic Myocardium: Answering the Basic Questions of Bone Marrow Stromal Cell Migration, Homing and Survival Under in Vivo and In Vitro Conditions"

Takeshi Oyaizu, MD, PhD
Toronto General Hospital, Toronto, ON, Canada
"Nano-technology Based Delivery of Src. Inhibitor to Prevent Lung Ischemia Reperfusion Injury"
 

2006

Rachel L. Anderson, MBBS
University of Newcastle, Newcastle Upon Tyne, United Kingdom
"Antimicrobial Peptides and Respiratory Pathogens in the Development of Chronic Allograft Dysfunction After Human Lung Transplantation"

Zhaohui Li, PhD
Baylor College of Medicine, Houston, TX, USA
"Generation and Characterization of a Heart Failure Mice Model Expressing a ZASP Cardiac Specific Isoform"

Heather E. Merry, MD
University of Washington, Seattle, WA, USA
"The Role of Innate Immunity in Lung Ischemia Reperfusion Injury"

Edward N. Seung, PhD
Massachusetts General Hospital, Boston, MA, USA
"Role of Effector T Cell Trafficking in Treg Function During Acute Lung Rejection"

Matthew J. Weiss, MD
Massachusetts General Hospital, Boston, MA, USA
"Using Mixed Chimerism to Induce Tolerance in Porcine Lung Allograft Recipients"
 

2005

Ryan C. Fields, MD
Washington University, St. Louis, MO, USA
"Immune Mechanisms of Rejection in Human Lung Allografts"

Arne Nyerinck, MD
Catholic University Leuven, Leuven, Belgium
"Comparative Study of Lung Injury in Heart-Beating Versus Non-Heart-Beating Donor"

Ahmad Saad, MD
Yale University, New Haven, CT, USA
"Tertiary Lymphoid Organs in Atherosclerotic Diseases and Their Role in Host vs Graft Rejection in Heart Transplantation"
 

2004

Christian A. Gleissner, MD
University of Heidelberg, Heidelberg, Germany
"IL-10 Inhibits Endothelium-Dependent T Cell Alloactivation: Molecular Mechanisms and In Vivo Relevance"

Tsuyoshi Shoji, MD, PhD
Massachusetts General Hospital, Boston, MA, USA
"Induction of Tolerance to Indirectly Presented Alloantigen by Loading Host Dendritic Cells With Donor Peptides in a Miniature Swine Lung Transplantation Model"

Kendra N. Taylor, PhD
Brigham & Women's Hospital, Boston, MA, USA
"Assessment of Innate Immune Activation and Toll-Like Receptor Function Within Lung Transplant Patients"

Monika Zwierzchoniewska, MD
Stanford University, Palo Alto, CA, USA
"Contribution of Neonatal Cardiac Myosin to Heart Allograft Survival"
 

2003

Felix Fernandez, MD
University of Washington School of Medicine, St. Louis, MO, USA
"Role of Matriz Metalloproteinase-2 in the Pathogenesis of Post-transplant Obliterative Airway Disease"

Ewout J. can den Bos, MD
University Medical Center Rotterdam, The Netherlands
"Tracking of Progenitor Cells in the Coronary Circulation with Magnetic Resonance Imaging"
 

2002

Ruediger Hoerbelt, MD
Massachusetts General Hospital, Boston, MA, USA
"Studies to Elucidate the Role of Activation-Induced Cell Death in the Induction of Tolerance in Miniature Swine Using Rapamycine, Donor-Specific Transfusions and Costimulation Blockade."

Markus Riha, MD
University of Pennsylvania, Philadelphia, PA, USA
"Ventricular Tissue Engineering: The Role of Acellular Matrix in Guided Cardiac Regeneration"
 

2001

Arnar Geirsson, MD
Yale University School of Medicine, New Haven, CT, USA
"Characterization of Throphoblast Factor Suppressing MHC Class II Expression"

Matteo Vatta, PhD
Baylor College of Medicine, Houston, TX, USA
"Dystrophon Disruption in End-Stage Cardiomyopathies"
 

2000

Richard S. Lee, MD
Massachusetts General Hospital, Boston, MA, USA
"Mechanisms and Treatment of Cardiac Allograft Vasculopathy in Miniature Swine Using Costimulatory Blockade and Donor MHC Allopeptides"

Douglas N. Miniati, MD
Stanford University, Palo Alto, CA, USA
"The Role of BCL-2 in the Oxidative Stress Signaling Pathways Following Cardiac Transplantation"

Christopher H. Wigfield, FRCS
Freeman Hospital and University of Newcastle Upon Tyne, Newcastle Upon Tyne, United Kingdom
"Brain Death Cytokine Induced Donor Organ Injury: Amelioration of Early Graft Dysfunction and Lung Transplantation"
 

1999

Donald C.K. Wong, PhD
The University of British Columbia, Vancouver, Canada
"The Relationship Between VEGF Induced Vascular Permeability and Atherosclerosis: Implications for Transplant Vascular Disease"

George Juang, MD
The Johns Hopkins University, Baltimore, MD, USA
"The Regulation of Potassium Channels Involved in Sudden Cardiac Death Failure"

Satoshi Saito, MD
University of California School of Medicine, Los Angeles, CA, USA
"TGF-Beta Gene Therapy in Cardiac Allograft Rejection"

SivaSai S.R. Krovvidi, PhD
Washington University School of Medicine, St.Louis, MO, USA
"Indirect Recognition of Donor HLA Class Peptides and its Role in the Pathogenesis of Bronshiolitis Obliterans Syndrome in Lung Transplant Recipients"
 

1998

Kelly SA Blair, MD
Vanderbilt University Medical Center, Nashville, TN, USA
"CD40L in Primate Allograft Tolerance and Viral Immunity"

A.M. El Gamel, MD
Wythenshawe Hospital, Manchester, United Kingdom
"Cytokine Genotype and Accelerated Coronary Disease Following Cardiac Transplantation"

Alyssa M. Krasinskas, MD
University of Pennsylvania Medical Center, Philadelphia, PA, USA
"The Role of Bone Marrow-Derived Elements in Allograft Rejection"

Christine L. Lau, MD
Duke University Medical Center, Durham, NC, USA
"The Role of Antibodies in Discordant Pulmonary Xenograft Rejection"

Scott D. Ross, MD
University of Virginia Health Science Center, Charlottesville, VA, USA
"Living Related Pulmonary Lobar Transplantation"

Margaret L. Schwarze, MD, MPP
Massachusetts General Hospital, Cambridge, MA, USA
"The "Thymoheart" Allograft: Effects of Vascularized Donor Thymus on Chronic Rejection and Xenotransplantation"
 

1997

Owen T. Lawrence, MD
University of Washington Medical Center, Seattle, WA, USA
"Improving Liposome Transfection Efficiency for Genetic Manipulation of Donor Endothelium: Novel Methodology Without Viral Genes"

Jonathen Chen, MD
Columbia-Presbyterian Medical Center, New York, NY, USA
"Correlating Donor-Specific Endothelial Cell Alloreactivity with Transplant Coronary Artery Disease"

Anne K. Raisanen-Sokolowski, MD
Harvard School of Public Health, Boston, MA, USA
"Transplant Arteriosclerosis in Cardiac Allografts: Use of Knockout Mice to Study Roles of ICAM-1 and P-Selectin"
 

1996

Andrew F. Pierre, MD
The Toronto Hospital, Toronto, ON, Canada
"The Role of Complement in Lung Transplantation"

Tuija S. Ikonen, MD
Stanford University School of Medicine, Stanford, CA, USA
"Chronic Rejection After Lung Transplantation - An Experimental Study on Obliterative Bronchiolitis and its Prevention"
 

1995

Frances L. Johnson, MD
Stanford University School of Medicine, Stanford, CA, USA
"Porcine Hematopoietic Stem Cells in Cardiac Xenotransplantation"