Cardiogenic Shock Research Grant

Supported by Abiomed

This grant will fund research that focuses on any or all of these areas:
  1. Early identification of patients with heart failure cardiogenic shock, best practices for device selection and escalation, and/or weaning strategies (Cardiogenic Shock)
  2. Criteria for the use of tMCS to optimize outcomes and promote heart recovery, including patient management, combined therapies, and mechanistic understanding (Heart Recovery)
  3. Artificial intelligence, machine learning, and data science to develop predictive modeling for native heart recovery in patients on tMCS (Predictive Modeling)

This grant is aimed at supporting rising stars in the field of heart failure or cardiac surgery who are experienced with the use of tMCS for cardiogenic shock. The grant recipient(s) will have already established a track record in cardiogenic shock and will aim to further develop their career(s) in this area.

The intent is that the grant recipient(s) will be junior faculty (i.e., has not previously received a major grant) and is dedicated to a career in the use of MCS to optimize outcomes in cardiogenic shock. It is anticipated that the individual will be a clinician/clinician scientist (physician, allied health or nurse) at an active cardiogenic shock program with a faculty appointment in either cardiology, critical care, or cardiac surgery.


The purpose of this grant is to support research that would enhance the understanding and management of cardiogenic shock in the setting of heart failure to optimize clinical outcomes and promote native heart recovery using temporary mechanical circulatory support (tMCS).

Grant Details

One or more grants will be awarded for the funding duration of two years at a budget of up to $140,000.
  • Academic Appointment and Institutional Resources:
    1. The applicant must have an academic or clinical appointment or may be in training at an accredited institution.
    2. A letter of institutional commitment from a division or department chair at the institution at which the research will be conducted must be provided.
  • ISHLT Membership
    1. The applicant must be an active member of ISHLT or have submitted a completed membership application by December 31, 2022.
  • Previous ISHLT Funding/Funding from Other Sources
    1. There are no restrictions on past or current funding.
      1. The applicant may be a past or current recipient of ISHLT funding including Fellowship or Faculty Development research grants.
      2. The applicant may currently hold career development awards, mentoring awards, or other independent research awards.
    2. If the applicant is currently receiving funding for a project similar to the topics described in this request for applications, the applicant must explain how the funds of the grant would not overlap with the funds of the other research support.
  • Miscellaneous
    1. Applicants who have a substantial relationship with Abiomed that would present a real or perceived conflict of interest if awarded this grant must first contact ISHLT to declare the conflict before submitting an application. Examples of a substantial relationship with an industry partner include: board member, member of advisory council, consultant, lecturer, etc.
      1. Employees of Abiomed cannot submit an application.
      2. Upon disclosure, the Grants and Awards Committee will determine if the individual is eligible to submit an application and will notify the individual in a timely manner.
Please review these guidelines and terms prior to completing your application. If you are ultimately awarded a grant, you will sign a letter of agreement (LOA) stating that you agree to these funding guidelines and terms, and the LOA will be co-signed by your institution’s grants/research office.
  1. Research is anticipated to begin on July 1, 2023.
  2. Funding in an amount of up to $140,000 will be provided for the research project.
  3. Funding will not be released until visa status is confirmed (if applicable).
  4. The grant is intended to provide salary support for the researcher, other study personnel, statistical support, supplies/materials, publication costs and travel related costs for abstract presentation and up to 10 percent of the grant can be used for institutional overhead. No other costs are permitted.
  5. The grant will be paid in multiple installments to the recipient’s institution. First installment (50% of funds) will be paid at the beginning of grant work; the second installment (25%) will be paid mid-award (after receipt of a grant progress report) and the final installment (25%) will be paid after receipt of a final report.
  6. Grant funding is generally not transferable from one recipient to another; transfer may be considered under compelling circumstances (e.g., the grantee leaves the institution and does not request a transfer of the grant, or the grantee requires an extended medical leave).
  7. If the grantee relocates and does not request a transfer of the grant to the new location, the current institution (i.e., department chair or division chair and Office of Sponsored Research) may select a new PI. The Grants and Awards Committee will determine if the grant can be continued at the current institution.
  8. If the grantee relocates, the Grants and Awards Committee will determine if the grant can be transferred to the recipient’s new location, or if the grant must be surrendered and any remaining funds returned. If the grant is surrendered, a final report will still be required (see number 11 below)
  9. The applicant must acknowledge the grant as a funding source in all manuscripts and presentations derived from the funded research using the following statement: “This work was supported by a grant from AbioMed and the International Society for Heart and Lung Transplantation.” Copies of such publications must be submitted to ISHLT.
  10. Pursuant to regulations of the federal Physician Payment Sunshine Act (included in the Affordable Care Act), NPI numbers will be collected from grant recipients (if applicable), and tax ID numbers collected from the recipients’ institutions (if applicable). All payments will be reported to the Centers for Medicare and Medicaid Services Open Payments system, as payments from ISHLT represent indirect transfers of value from the funding pharmaceutical company.
  11. Reports are required at the following intervals depending on the term of the grant, and continuation of funding is contingent upon completion of these reports:
    1. Mid-award progress report due June 30, 2024. Continued funding will be contingent on progress made during the first grant year.
    2. Final report within 30 days of the conclusion of the grant term (June 30, 2025).
      1. A final report is required even if the grant is surrendered for any reason prior to the conclusion of the grant term.
  1. Proposals are due by January 16, 2023.
  2. Selection of the grant recipient(s) will be made by an expert review committee from ISHLT.
  3. Grants will be scored on factors including but not limited to study aims, significance, innovation, research approach, feasibility of obtaining relevant data, and prior work.
  4. All applicants will be notified as to whether or not they have been selected to receive the research grant by March 15, 2023.
  5. The term of the grant will begin July 1, 2023.

Current Grant Recipient

Thomas Hanff, MD, MSCE
University of Utah, Salt Lake City, UT USA
Project: "Angiotensin II Deficiency in Cardiogenic Shock: Using Novel Translational Insights into Cardiogenic Shock Pathophysiology to Guide the Timing and Optimal Use of Temporary Mechanical Circulatory Support"

Paolo Meani, MD, PhD
Maastricht University, Maastricht, Netherlands
Project: "A Multicentric Left Ventricular Venting Strategy Comparison in Patients Receiving Extracorporeal Life Support - A Prospective Observational Study"