ISHLT 2023 Annual Meeting Awards Showcase Advances in Treatment of Advanced Heart and Lung Disease

Fourteen presenters from six countries were recognized for excellence for their presentations on machine learning, non-invasive therapy techniques, barriers to donor acceptance, and more.


 
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CHICAGO, USA – 2 June, 2023 – The International Society for Heart and Lung Transplantation 43rd Annual Meeting & Scientific Sessions included more than 1,250 presentations on improving outcomes for patients with advanced heart and lung disease from investigators from around the world.

The Society recognized selected 14 presentations for excellence within each of the ten professional communities that make up ISHLT’s multidisciplinary membership, as well as specific awards to recognize excellence from early career investigators. All conference abstracts are available in a special supplement to The Journal of Heart and Lung Transplantation’s April 2023 issue.

The Philip K. Caves Award, Early Career Scientist Award, and Early Career Clinical Case Dilemmas Best Presentation Award encourage and reward original high-quality research from trainees, residents, fellows, graduate students, and young researchers in fields across advanced heart and lung disease and transplantation.
 
PHILIP K. CAVES AWARD
Awarded to: Brian Wayda, MD, MPH
Stanford University School of Medicine in Stanford, CA USA
Presentation Title: Prediction of Donor Heart Acceptance for Transplant: Results From the Donor Heart Study
Purpose: Despite a scarcity of potential donors for heart transplantation in the United States, a minority are actually accepted for transplantation. The team evaluated donor characteristics associated with heart acceptance in the USA and applied modern analytic methods to improve the prediction of heart acceptance.
 
EARLY CAREER SCIENTIST AWARD
Awarded to: Sambavan Jeyakumar
University of New South Wales in Sydney, Australia
Presentation Title: Retinal Microvascular Remodelling Predicts Adverse Events in Continuous-Flow Left Ventricular Assist Device Supported Patients
Purpose: Continuous-flow left ventricular assist device (cfLVAD) support affects flow pathways within the microcirculation. The team aimed to profile changes within retinal microvasculature and its association with adverse events.
 
ISHLT/ICCAC VAD COORDINATOR CAREER DEVELOPMENT GRANT
Given by ISHLT in partnership with the International Consortium of Circulatory Assist Clinicians (ICCAC)
Awarded to: Rossa Brugha, BMBCh, MA(Oxon), MRCPCH, PhD
Great Ormond Street Hospital in London, UK
Presentation Title: Cytotoxic T-Lymphocyte Therapy for Post-transplant Lymphoproliferative Disease in an Adolescent Following Lung Transplantation
Purpose: This case study examines a patient with post-transplant lymphoproliferative disease who was treated with cytotoxic T-lymphocytes to clear her cancer.

The ISHLT Professional Community Awards for Excellence recognize the contributions made across the care continuum by ISHLT members, encouraging investigation and professional excellence in a wide variety of specialties.
 
ANESTHESIOLOGY & CRITICAL CARE PROFESSIONAL COMMUNITY AWARD FOR EXCELLENCE
Awarded to: Leonardo Salazar, MD, MSc
FundaciĆ³n Cardiovascular de Colombia in Floridablanca, Colombia
Presentation Title: Left Ventricular Assist Device Implantation Outcomes: Single-Center Experience in a Latin American Advanced Heart Failure Reference Program
Purpose: The team examined durable left ventricular assist device (LVAD) experiences in an advanced heart failure program in a developing country, evaluating the actuarial survival and adverse events rate in a cohort of patients implanted in the largest MCS program in Colombia.
 
CARDIOLOGY PROFESSIONAL COMMUNITY AWARD FOR EXCELLENCE
Awarded to: Christos Kyriakopoulos, MD
University of Utah in Salt Lake City, UT USA
Presentation Title: Multicenter Development and Validation of a Machine Learning Model to Predict Myocardial Recovery During LVAD Support: The UCAR Score
Purpose: The team sought to create a pre-LVAD clinical tool to assess the likelihood of functional and structural cardiac improvement following LVAD support, independently of the complex and confounded decision of LVAD removal/weaning.
 
CARDIOTHORACIC SURGERY PROFESSIONAL COMMUNITY AWARD FOR EXCELLENCE
Awarded to: Ezequiel Molina, MD, FACS
Piedmont Heart Institute in Atlanta, GA USA
Presentation Title: The Impact of Small Left Ventricular Dimension on Outcomes after HeartMate 3 LVAD Implantation
Purpose: A patient-specific risk score, which includes Left Ventricular End Diastolic Diameter (LVEDD) <55mm as one of 6 core components, was developed to predict survival following HeartMate 3 (HM3) left ventricular assist device (LVAD) implantation. The team compared this finding with comprehensive clinical outcomes in a prospective clinical trial cohort.
 
INFECTIOUS DISEASES PROFESSIONAL COMMUNITY AWARD FOR EXCELLENCE
Awarded to: Saima Aslam, MD, MS
University of California San Diego in San Diego, CA USA
Presentation Title: Development of Burkholderia Cepacia Complex Targeted Clinical Registry and Phage Library
Purpose: The team developed a multi-center international registry of BCC-infected patients with CF and/or lung transplant and used their bacterial isolates to develop a new targeted library of 25 lytic phages that cover 85% of isolates. This phage library will be used for treatment in both compassionate use and clinical trial settings.
 
NURSING & ALLIED HEALTH PROFESSIONAL COMMUNITY AWARD FOR EXCELLENCE
Awarded to: Kathy Grady, PhD, RN, MS, FAAN
Northwestern University in Chicago, IL USA
Presentation Title: A Comparison of Quality-Adjusted Life Years in Older Adults after Heart Transplantation Versus Long-Term Mechanical Support: Findings from SUSTAIN-IT
Purpose: The Quality-Adjusted Life Year (QALY) is a measure of the burden of disease and its treatment that combines survival and health-related quality of life (HRQOL). The study aims to describe QALYs in 3 groups of older patients with heart failure (HF) who undergo heart transplantation (HT) or long-term MCS, if ineligible for HT.
 
PATHOLOGY PROFESSIONAL COMMUNITY AWARD FOR EXCELLENCE
Awarded to: Francesca Lunardi, MD, ScD, PhD
University of Padova in Padova, Italy
Presentation Title: Phosphorylated S6 Ribosomal Protein as an Additional Marker of Antibody-Mediated Rejection in Lung Allografts: A Multicentre Study
Purpose: The mammalian target of rapamycin pathways, specifically p-S6RP, is associated with cardiac pAMR and recently correlated with de novo donor-specific antibodies in lung transplantation. The main goal of this study was to assess tissue p-S6RP expression in patients with lung AMR in an attempt to identify tissue biomarkers useful for more sensitive diagnosis of AMR.
 
PEDIATRICS PROFESSIONAL COMMUNITY AWARD FOR EXCELLENCE
Awarded to: Madeleine Townsend, MD
Cleveland Clinic Children’s in Cleveland, OH USA
Presentation Title: Statin Use May Not Benefit Pediatric Heart Transplant Recipients: A PHTS Analysis
Purpose: Despite robust data in adults supporting the use of statin medications to prevent development of post-heart transplant cardiac allograft vasculopathy (CAV), there is no large-scale data in children showing benefit from statins. Through a retrospective study of children from the Pediatric Heart Transplant Society database, the team sought to evaluate the contemporary prevalence and trends of statin use in pediatric HTRs and the association between statin use and graft failure, CAV, and rejection.
 
PHARMACY PROFESSIONAL COMMUNITY AWARD FOR EXCELLENCE
Awarded to: Erik Henricksen, PharmD
Stanford Medicine in Stanford, CA USA
Presentation Title: Bye-Bye Biopsy? Comparing Short and Long-Term Outcomes after Adopting Early Non-Invasive Rejection Surveillance
Purpose: This single center study sought to assess the impact of the early introduction of ddcfDNA, and later paired with GEP as compared to a strategy of GEP testing alone on the number of endomyocardial biopsies and clinical outcomes at three years.
 
PULMONOLOGY PROFESSIONAL COMMUNITY AWARD FOR EXCELLENCE
Awarded to: Reda Girgis, MD
Spectrum Health / Michigan State University in Grand Rapids, MI USA
Presentation Title: Predictors of Early Mortality after Lung Transplantation for Primary Pulmonary Hypertension: A UNOS Analysis
Purpose: Idiopathic pulmonary arterial hypertension (formerly PPH) continues to have a high mortality rate, despite medical therapy. However, long-term survival conditional upon 3 m survival is among the best. This research analyzed the UNOS transplant database to assess the determinants of early mortality after lung transplantation for primary pulmonary hypertension.
 
RESEARCH & IMMUNOLOGY PROFESSIONAL COMMUNITY AWARD FOR EXCELLENCE
Awarded to: Pieterjan Kerckhof, IR, MD
KU Leuven in Leuven, Belgium
Presentation Title: Morphometric Airway Changes in Explanted Human Lungs with Chronic Lung Allograft Dysfunction
Purpose: Chronic lung allograft dysfunction (CLAD) remains a major complication after lung transplantation, encompassing two main phenotypes: bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS). This study’s aim was to characterize the morphological airway changes in end-stage BOS and RAS.
 
RESEARCH & IMMUNOLOGY PROFESSIONAL COMMUNITY AWARD FOR EXCELLENCE
Awarded to: Kristina Andrijauskaite, PhD, MS, MEd
Vascular Perfusion Solutions, Inc. in San Antonio, TX USA
Presentation Title: Novel Portable Hypothermic Perfusion Preservation Device Enhances Cardiac Output of Donated Human Hearts
Purpose: Heart transplant remains the gold standard treatment for patients with advanced heart failure. However, the list of patients waiting for a heart transplant continues to increase. The team developed a portable hypothermic oxygenated machine perfusion device, the VP.S ENCORE™, to extend the allowable preservation time. After demonstrating successful preservation of cardiac grafts in preclinical animal models, the purpose of this study was to test the efficacy of the VP.S. ENCORE™ using deceased donors derived hearts.
 

For more information about each of the awards, visit https://ishlt.org/research-data/grants-awards/scientific-abstract-awards.
 


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About ISHLT
The International Society for Heart and Lung Transplantation is a not-for-profit, multidisciplinary professional organization dedicated to improving the care of patients with advanced heart or lung disease through transplantation, mechanical support and innovative therapies. With more than 3,800 members in more than 45 countries, ISHLT is the world’s largest organization dedicated to the research, education and advocacy of end-stage heart and lung disease. ISHLT members represent more than 15 different professional disciplines. For more information, visit www.ishlt.org.